GreatPoint Energy, founded in 2004, is commercializing a new process to produce low cost substitute natural gas from coal. The company is developing an advanced catalytic gasification technology to convert low grade sub-bituminous and lignite coals to a high value pipeline grade gas. In addition to lower cost, GPE will provide a domestically sourced fuel gas with substantially less price volatility than natural gas and a similarly clean environmental profile. The goal of the company is to build, own and operate gas production facilities and to sell substitute natural gas to distressed natural gas power plant operators and large industrial users.

Coskata is a biology-based renewable energy company. Our technology enables the low-cost production of ethanol from a wide variety of input material including biomass, municipal solid waste and other carbonaceous material. Using proprietary microorganisms and patented bioreactor designs, we will produce ethanol for under US$1.00 per gallon.

Ethos was established in 2007 to produce low cost ethanol and related biofuels in the CAFTA, CBI and ATP regions of Central and South America as well as the CaribbeanBasin. Ethos, founded by GreatPoint Ventures and Khosla Ventures, is focused on leveraging partnerships with well-entrenched local groups in relevant agribusinesses to acquire underutilized sugar mills and sugarcane lands and to modernize them for biofuels production. As a project development company, Ethos brings a dominant platform for low cost production of biofuels by combining best of breed partners, an advanced technology portfolio and experienced founders with a track record of building successful alternative energy businesses.

AltaRock develops and commercializes geothermal technology to produce clean, renewable power.

Oasys (Osmotic Application Systems) is a Cambridge MA based company developing a suite of proprietary water treatment products to address the growing, global water crisis. The Company's Engineered Osmosis (EO™) process provides a novel treatment system that can produce clean, potable water at significantly lower cost than current desalination methods.

Zafgen is a product-focused biotechnology company created by GPV to commercialize novel therapeutics for the treatment of obesity and related diseases.

Sirtris Pharmaceuticals was founded in 2003 to commercialize a new family of Sirtuin activating compounds (STACs) to treat cancer, heart disease, and diabetes. The STAC technology utilizes stress induced cell defense mechanisms to slow aging and defend against disease. The company is now in the process of synthesizing chemical compounds to target specific organs and is conducting animal studies as it prepares to enter human trials. The company has raised $45 million from Three Arch Partners, Cargill Ventures, Novartis Bioventures Fund, Polaris Venture Partners, Techno Venture Management, Cardinal Partners, Skyline Ventures, and The Wellcome Trust.

Cignal Global Communications was founded in 1995 to provide international voice and data communications services. The company raised $55 million in venture capital and over $100 million in debt financing, built an ATM-based fiber-optic network connecting 22 countries in Europe and the Far East, employed 250 people and generated $60 million in revenues. Cignal's customers included AT&T, France Telecom, Deutche Telecom, MCI, China Telecom and many other leading global carriers. In 2000, Cignal was sold to United Pan-European Communications (NASDAQ: UCOMA), one of the largest cable operators in Europe.

Coatue Corporation is a microelectronics company formed in 2001 to develop novel ionic/electronic conducting polymer materials for use in the semiconductor industry. The company generated a portfolio of intellectual property, assembled a world-class team of scientists, built out a materials research facility and microelectronics lab, and invented a next generation Flash memory chip which is faster, lower power, and higher capacity than today’s leading semiconductors. In June 2003, Coatue was acquired by Advanced Micro Devices (NYSE: AMD), the world's largest manufacturer of flash memory chips.